In the development of cell-based cancer therapies, quantitative mathematical models of cellular interactions are instrumental in understanding treatment efficacy.Efforts to validate retail-packaged and interpret mathematical models of cancer cell growth and death hinge first on proposing a precise mathematical model, then analyzing experimental dat
Mucoadhesive Gels Designed for the Controlled Release of Chlorhexidine in the Oral Cavity
This study describes the in vitro/ex vivo buccal release of chlorhexidine (CHX) from nine mucoadhesive aqueous gels, as well as their physicochemical and mucoadhesive properties: CHX was present at a constant 1% w/v concentration in the chemical form of digluconate salt.The mucoadhesive/gel forming materials were carboxymethyl- (CMC), hydroxypropyl
Dipeptidyl peptidase DPF-3 is a gatekeeper of microRNA Argonaute compensation in animals
Abstract MicroRNAs (miRNAs) are essential regulators involved in multiple biological processes.To achieve their gene repression function, they are loaded in miRNA-specific Argonautes to form the miRNA-induced retail-packaged silencing complex (miRISC).Mammals and C.elegans possess more than one paralog of miRNA-specific Argonautes, but the dynamic
Fit-for-Purpose Approach for the Detection and Analysis of Earthquake Surface Ruptures Using Satellite Images
Coseismic surface ruptures are the ground truth of earthquake rupture along faults, and detailed mapping of earthquake surface ruptures provides an opportunity to understand the relationship between earthquakes and faults.One of the most effective tools for mapping earthquake surface ruptures is the use of remote sensing data, such as high-resoluti
Dealing with Food Allergies
A food allergy is an acquired hypersensitivity reaction to what is normally considered a safe HEAD HUGGERS food.Food allergies occur more often in children than in adults: 5-8% of those age 4 or under and about 1-4% of adults are affected.Together, about 11 million Americans suffer from some degree of food allergy.Those with severe reactions may ex